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人IPSC来源神经干细胞(阿尔海默氏APOE4 HOM)  英国Axol原装   ax0111

现价: 8000.00
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Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (APOE4 HOM). 1 vial of Neural Stem Cells (1.5 million cells) and 1 bottle of Neural Plating-XF Medium (30 mL).

Axol Human iPSC-Derived Neural Stem Cells (NSCs) are derived from integration-free, induced pluripotent stem cells (iPSCs) under fully defined neural induction conditions. The NSCs express typical markers of cerebral cortical neural stem and progenitor cells such as PAX6, FOXG1 and nestin, and spontaneously form polarized neural tube-like rosette structures when plated as a monolayer in culture (see below). Additionally, Axol NSCs are capable of generating a spectrum of cerebral cortical excitatory and inhibitory neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. After thawing and plating, the neural stem cells terminally differentiate to acquire mature electrophysiological properties, and form functional synaptic networks over a period of 40 ~ 50 days.

Axol NSCs are easy to differentiate to neurons or mixed neural cell types, following our protocols and using our tailored media and reagent bundles. A highly pure population of neurons can be generated from Axol NSCs following the synchronous differentiation protocol. Using our specialized coating reagents, neurons derived from Axol NSCs can be maintained in culture long-term (>1 year). NSCs are available from multiple donors to suit your research needs and have been characterized extensively.


Starting material

Dermal fibroblast

Donor gender

Female

Donor age at sampling

87 yrs

HLA serotype

A2 A68, B13(Bw4) B49(Bw4), Cw6 Cw7

Reprogramming method

Episomal vector

Induction method

Monolayer & chemically defined medium

Genetic modification

None

Size

≥1.5 million cells

Kit components

1 vial of Neural Stem Cells (≥1.5 million cells) and 1 bottle of Neural Plating-XF Medium (30 mL)

Cell type

iPSC-derived neural stem cells

Growth properties

Adherent

Mutation

APOE4 homozygous

Disease information

The donor (Caucasian) had autopsy-confirmed Alzheimer's Disease with an onset of symptoms after age 70. The donor's parent and 3 siblings were also affected. The donor was homozygous for the 4 allele of apolipoprotein E.

Shipping conditions

Dry ice

Storage conditions

Liquid nitrogen