Cloud Zoom small image
基因改造iPSC来源的神经干细胞MAPT V337M HOM      英国Axol原装    ax0322

现价: 0.00
¥0
节省
¥0
市场价格
当前销售数量: 93
折扣:0折
本单还可以继续购买
数量:

库存0

  • 产品描述
  • 产品特性
  • 评价

axolGEM iPSC-Derived Neural Stem Cells MAPT V337M HOM (1.5 million cells) and Neural Plating-XF Medium (30 mL).

Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the V337M mutation (GTG>ATG) in the MAPT gene. This line is homozygous for the V337M mutation so both alleles contain the mutation. Click on the product images to see the data and further details.

The V337M mutation in MAPT has been implicated in frontotemporal dementia and may have a role in Alzheimer's disease. The mutation leads to accelerated aggregation of MAPT/tau protein into filament structures (Nacharaju et al., 1999) and makes the MAPT/tau protein more susceptible to hyperphosphorylation (Alonso et al., 2004).

Starting material Dermal fibroblast
Donor gender Female
Donor age at sampling 64 yrs
Karyotype Normal
Reprogramming method Episomal vector
Induction method Monolayer & chemically defined medium
Genetic modification Homozygous for the MAPT V337M mutation (GTG>ATG)
Genetic modification Contains a puromycin resistance cassette (intronic)
Size ≥1.5 million cells
Kit components 1 vial of Neural Stem Cells (≥1.5 million cells) and 1 bottle of Neural Plating-XF Medium (30 mL)
Growth properties Adherent
Shipping conditions Dry ice
Storage conditions Liquid nitrogen